Increased EEG delta frequency corresponds to chorioamnionitis-related brain injury (2024)

Gavilanes, A. W. D., Gantert, M., Strackx, E., Zimmermann, L. J., Seeldrayers, S., Vles, J. S. H., & Kramer, B. W. (2010). Increased EEG delta frequency corresponds to chorioamnionitis-related brain injury. Frontiers in bioscience - scholar edition, 2, 432-438. https://doi.org/10.2741/S76

Gavilanes, Antonio Wenceslao Danilo ; Gantert, Markus ; Strackx, Eveline et al. / Increased EEG delta frequency corresponds to chorioamnionitis-related brain injury. In: Frontiers in bioscience - scholar edition. 2010 ; Vol. 2. pp. 432-438.

@article{435caede3a64410b983af2d49fe1e666,

title = "Increased EEG delta frequency corresponds to chorioamnionitis-related brain injury",

abstract = "We evaluated the impact of chorioamnionitis on the intrapartal EEG delta frequency in the non-anesthetized preterm sheep. 10 mg intra-amniotic LPS or saline were given 2 or 14 days before preterm birth at gestational day 125. Lambs were delivered by Caesarean section under local anesthesia. A 5-minute EEG depicted delta activity and amplitude, and the relationship between EEG delta activity and both the white matter (WM) and cortical microglial activation and apoptosis was analyzed. EEG delta activity was increased significantly in the 14-day LPS preterm fetuses compared to both preterm control and 2-day LPS animals (p less than 0.05). No differences were seen between controls and the 2-day LPS fetuses. A direct association was demonstrated between EEG delta activity and both cortical microglial activation (r = 0,645, p = 0,024) and apoptosis (r = 0,580, p = 0,048), and between delta and WM activated microglia (r = 0,742, p = 0,006) and apoptosis (r = 0,777, p = 0,003). This study is the first to show a relationship between brain dysfunction and chorioamnionitis-related injury at birth.",

keywords = "Analysis of Variance, Animals, Apoptosis, Biomarkers, Brain, Chorioamnionitis, Delta Rhythm, Female, Flow Cytometry, Microglia, Pregnancy, Premature Birth, Sheep, Journal Article",

author = "Gavilanes, {Antonio Wenceslao Danilo} and Markus Gantert and Eveline Strackx and Zimmermann, {Luc J} and Saskia Seeldrayers and Vles, {Johan S H} and Kramer, {Boris W}",

year = "2010",

month = jan,

day = "1",

doi = "10.2741/S76",

language = "English",

volume = "2",

pages = "432--438",

journal = "Frontiers in bioscience - scholar edition",

issn = "1945-0516",

publisher = "Frontiers in Bioscience",

}

Gavilanes, AWD, Gantert, M, Strackx, E, Zimmermann, LJ, Seeldrayers, S, Vles, JSH & Kramer, BW 2010, 'Increased EEG delta frequency corresponds to chorioamnionitis-related brain injury', Frontiers in bioscience - scholar edition, vol. 2, pp. 432-438. https://doi.org/10.2741/S76

Increased EEG delta frequency corresponds to chorioamnionitis-related brain injury. / Gavilanes, Antonio Wenceslao Danilo; Gantert, Markus; Strackx, Eveline et al.
In: Frontiers in bioscience - scholar edition, Vol. 2, 01.01.2010, p. 432-438.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Increased EEG delta frequency corresponds to chorioamnionitis-related brain injury

AU - Gavilanes, Antonio Wenceslao Danilo

AU - Gantert, Markus

AU - Strackx, Eveline

AU - Zimmermann, Luc J

AU - Seeldrayers, Saskia

AU - Vles, Johan S H

AU - Kramer, Boris W

PY - 2010/1/1

Y1 - 2010/1/1

N2 - We evaluated the impact of chorioamnionitis on the intrapartal EEG delta frequency in the non-anesthetized preterm sheep. 10 mg intra-amniotic LPS or saline were given 2 or 14 days before preterm birth at gestational day 125. Lambs were delivered by Caesarean section under local anesthesia. A 5-minute EEG depicted delta activity and amplitude, and the relationship between EEG delta activity and both the white matter (WM) and cortical microglial activation and apoptosis was analyzed. EEG delta activity was increased significantly in the 14-day LPS preterm fetuses compared to both preterm control and 2-day LPS animals (p less than 0.05). No differences were seen between controls and the 2-day LPS fetuses. A direct association was demonstrated between EEG delta activity and both cortical microglial activation (r = 0,645, p = 0,024) and apoptosis (r = 0,580, p = 0,048), and between delta and WM activated microglia (r = 0,742, p = 0,006) and apoptosis (r = 0,777, p = 0,003). This study is the first to show a relationship between brain dysfunction and chorioamnionitis-related injury at birth.

AB - We evaluated the impact of chorioamnionitis on the intrapartal EEG delta frequency in the non-anesthetized preterm sheep. 10 mg intra-amniotic LPS or saline were given 2 or 14 days before preterm birth at gestational day 125. Lambs were delivered by Caesarean section under local anesthesia. A 5-minute EEG depicted delta activity and amplitude, and the relationship between EEG delta activity and both the white matter (WM) and cortical microglial activation and apoptosis was analyzed. EEG delta activity was increased significantly in the 14-day LPS preterm fetuses compared to both preterm control and 2-day LPS animals (p less than 0.05). No differences were seen between controls and the 2-day LPS fetuses. A direct association was demonstrated between EEG delta activity and both cortical microglial activation (r = 0,645, p = 0,024) and apoptosis (r = 0,580, p = 0,048), and between delta and WM activated microglia (r = 0,742, p = 0,006) and apoptosis (r = 0,777, p = 0,003). This study is the first to show a relationship between brain dysfunction and chorioamnionitis-related injury at birth.

KW - Analysis of Variance

KW - Animals

KW - Apoptosis

KW - Biomarkers

KW - Brain

KW - Chorioamnionitis

KW - Delta Rhythm

KW - Female

KW - Flow Cytometry

KW - Microglia

KW - Pregnancy

KW - Premature Birth

KW - Sheep

KW - Journal Article

U2 - 10.2741/S76

DO - 10.2741/S76

M3 - Article

C2 - 20036959

SN - 1945-0516

VL - 2

SP - 432

EP - 438

JO - Frontiers in bioscience - scholar edition

JF - Frontiers in bioscience - scholar edition

ER -

Gavilanes AWD, Gantert M, Strackx E, Zimmermann LJ, Seeldrayers S, Vles JSH et al. Increased EEG delta frequency corresponds to chorioamnionitis-related brain injury. Frontiers in bioscience - scholar edition. 2010 Jan 1;2:432-438. doi: 10.2741/S76